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TNIP1-mediated TNF-?/NF-?B signalling cascade sustains glioma cell proliferation.

ABSTRACT: As a malignant tumour of the central nervous system, glioma exhibits high incidence and poor prognosis. Although TNIP1 and the TNF-?/NF-?B axis play key roles in immune diseases and inflammatory responses, their relationship and role in glioma remain unknown. Here, we revealed high levels of TNIP1 and TNF-?/NF-?B in glioma tissue. Glioma cell proliferation was activated with TNF-? treatment and showed extreme sensitivity to the TNF receptor antagonist. Furthermore, loss of TNIP1 disbanded the A20 complex responsible for I?B degradation and NF-?B nucleus translocation, and consequently erased TNF?-induced glioma cell proliferation. Thus, our investigation uncovered a vital function of the TNIP1-mediated TNF-?/NF-?B axis in glioma cell proliferation and provides novel insight into glioma pathology and diagnosis.

SUBMITTER: Lei Q

PROVIDER: S-EPMC6933386 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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TNIP1-mediated TNF-α/NF-κB signalling cascade sustains glioma cell proliferation.

Lei Qingchun Q Gu Huan H Li Lei L Wu Tingting T Xie Wentao W Li Meizhang M Zhao Ninghui N

Journal of cellular and molecular medicine 20191105 1

As a malignant tumour of the central nervous system, glioma exhibits high incidence and poor prognosis. Although TNIP1 and the TNF-α/NF-κB axis play key roles in immune diseases and inflammatory responses, their relationship and role in glioma remain unknown. Here, we revealed high levels of TNIP1 and TNF-α/NF-κB in glioma tissue. Glioma cell proliferation was activated with TNF-α treatment and showed extreme sensitivity to the TNF receptor antagonist. Furthermore, loss of TNIP1 disbanded the A2 ...[more]

PMID: 31691497

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