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Genome Mining Reveals Neurospora crassa Can Produce the Salicylaldehyde Sordarial.


ABSTRACT: A highly reducing polyketide synthase gene cluster from the Magnaporthe oryzae genome was previously identified to produce phytotoxic compounds including pyriculol. A homologous gene cluster was found in Neurospora crassa through bioinformatics analysis. Heterologous expression of this cluster led to the production of the salicylic aldehyde sordarial and related intermediates. A series of combinatorial gene expression experiments established the set of enzymes required to produce sordarial and the likely biosynthetic pathway.

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC6933945 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Genome Mining Reveals Neurospora crassa Can Produce the Salicylaldehyde Sordarial.

Zhao Zhiyue Z   Ying Youmin Y   Hung Yiu-Sun YS   Tang Yi Y  

Journal of natural products 20190325 4


A highly reducing polyketide synthase gene cluster from the Magnaporthe oryzae genome was previously identified to produce phytotoxic compounds including pyriculol. A homologous gene cluster was found in Neurospora crassa through bioinformatics analysis. Heterologous expression of this cluster led to the production of the salicylic aldehyde sordarial and related intermediates. A series of combinatorial gene expression experiments established the set of enzymes required to produce sordarial and t  ...[more]

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