Genome Mining Reveals Neurospora crassa Can Produce the Salicylaldehyde Sordarial.
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ABSTRACT:
SUBMITTER: Zhao Z
PROVIDER: S-EPMC6933945 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Genome Mining Reveals Neurospora crassa Can Produce the Salicylaldehyde Sordarial.
Zhao Zhiyue Z Ying Youmin Y Hung Yiu-Sun YS Tang Yi Y
Journal of natural products 20190325 4
A highly reducing polyketide synthase gene cluster from the Magnaporthe oryzae genome was previously identified to produce phytotoxic compounds including pyriculol. A homologous gene cluster was found in Neurospora crassa through bioinformatics analysis. Heterologous expression of this cluster led to the production of the salicylic aldehyde sordarial and related intermediates. A series of combinatorial gene expression experiments established the set of enzymes required to produce sordarial and t ...[more]
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