Ontology highlight
ABSTRACT:
SUBMITTER: Ron-Harel N
PROVIDER: S-EPMC6934407 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Ron-Harel Noga N Ghergurovich Jonathan M JM Notarangelo Giulia G LaFleur Martin W MW Tsubosaka Yoshiki Y Sharpe Arlene H AH Rabinowitz Joshua D JD Haigis Marcia C MC
Cell reports 20190901 12
T cell stimulation is metabolically demanding. To exit quiescence, T cells rely on environmental nutrients, including glucose and the amino acids glutamine, leucine, serine, and arginine. The expression of transporters for these nutrients is tightly regulated and required for T cell activation. In contrast to these amino acids, which are essential or require multi-step biosynthesis, alanine can be made from pyruvate by a single transamination. Here, we show that extracellular alanine is neverthe ...[more]