Glutaminase Inhibition on NSCLC Depends on Extracellular Alanine Exploitation.
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ABSTRACT:
SUBMITTER: Caiola E
PROVIDER: S-EPMC7465377 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Glutaminase Inhibition on NSCLC Depends on Extracellular Alanine Exploitation.
Caiola Elisa E Colombo Marika M Sestito Giovanna G Lupi Monica M Marabese Mirko M Pastorelli Roberta R Broggini Massimo M Brunelli Laura L
Cells 20200723 8
Non-small-cell lung cancer (NSCLC) cell lines vary in their sensitivity to glutaminase inhibitors, so it is important to identify the metabolic assets underling their efficacy in cancer cells. Even though specific genetic lesions such as in KRAS and LKB1 have been associated with reliance on glutamine for their metabolic needs, we found no distinction between glutaminase inhibitor CB-839 sensitivity and resistant phenotypes in NSCLC cells with or without these genetic alterations. We demonstrate ...[more]
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