Ontology highlight
ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC6934596 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Lee Jennifer J Jung Hyerin H Park Narae N Park Sung-Hwan SH Ju Ji Hyeon JH
Scientific reports 20191227 1
A three-dimensional (3D) culture system that closely replicates the in vivo microenvironment of calcifying osteoid is essential for in vitro cultivation of bone-like material. In this regard, the 3D cellulose constructs of plants may well serve as scaffolds to promote growth and differentiation of osteoblasts in culture. Our aim in this study was to generate bone-like tissue by seeding pluripotent stem cells (hiPSCs), stimulated to differentiate as osteoblasts in culture, onto the decellularised ...[more]