Ontology highlight
ABSTRACT:
SUBMITTER: Witwinowski J
PROVIDER: S-EPMC6934819 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Witwinowski Jerzy J Moutiez Mireille M Coupet Matthieu M Correia Isabelle I Belin Pascal P Ruzzini Antonio A Saulnier Corinne C Caraty Laëtitia L Favry Emmanuel E Seguin Jérôme J Lautru Sylvie S Lequin Olivier O Gondry Muriel M Pernodet Jean-Luc JL Darbon Emmanuelle E
Scientific reports 20191227 1
The 2,5-Diketopiperazines (DKPs) constitute a large family of natural products with important biological activities. Bicyclomycin is a clinically-relevant DKP antibiotic that is the first and only member in a class known to target the bacterial transcription termination factor Rho. It derives from cyclo-(L-isoleucyl-L-leucyl) and has an unusual and highly oxidized bicyclic structure that is formed by an ether bridge between the hydroxylated terminal carbon atom of the isoleucine lateral chain an ...[more]