Ontology highlight
ABSTRACT:
SUBMITTER: Chari JV
PROVIDER: S-EPMC6935045 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20190306 6
Silyl triflate precursors to cyclic alkynes and allenes serve as valuable synthetic building blocks. We report a concise and scalable synthetic approach to prepare the silyl triflate precursors to cyclohexyne and 1,2-cyclohexadiene. The strategy involves a retro-Brook rearrangement of an easily accessible cyclohexanone derivative, followed by triflation protocols. This simple, yet controlled, method should enable the further study of strained alkynes and allenes in chemical synthesis. ...[more]