Ontology highlight
ABSTRACT:
SUBMITTER: Wang N
PROVIDER: S-EPMC6935267 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Cell reports 20190901 13
Middle East respiratory syndrome coronavirus (MERS-CoV) emerged into the human population in 2012 and has caused substantial morbidity and mortality. Potently neutralizing antibodies targeting the receptor-binding domain (RBD) on MERS-CoV spike (S) protein have been characterized, but much less is known about antibodies targeting non-RBD epitopes. Here, we report the structural and functional characterization of G2, a neutralizing antibody targeting the MERS-CoV S1 N-terminal domain (S1-NTD). St ...[more]