Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC7104183 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Zhang Senyan S Zhou Panpan P Wang Pengfei P Li Yangyang Y Jiang Liwei L Jia Wenxu W Wang Han H Fan Angela A Wang Dongli D Shi Xuanling X Fang Xianyang X Hammel Michal M Wang Shuying S Wang Xinquan X Zhang Linqi L
Cell reports 20180701 2
The major mechanism of antibody-mediated neutralization of the Middle East respiratory syndrome coronavirus (MERS-CoV) involves competition with the cellular receptor dipeptidyl peptidase 4 (DPP4) for binding to the receptor-binding domain (RBD) of the spike (S) glycoprotein. Here, we report a unique epitope and unusual neutralizing mechanism of the isolated human antibody MERS-4. Structurally, MERS-4 approached the RBD from the outside of the RBD-DPP4 binding interface. Such binding resulted in ...[more]