Ontology highlight
ABSTRACT:
SUBMITTER: Gamache A
PROVIDER: S-EPMC6936569 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Gamache Awndre A Cronk John M JM Nash William T WT Puchalski Patryk P Gillespie Alyssa A Wei Hairong H Gray Laurie L Hammarskjold Marie-Louise ML Xu Wenhao W Brown Michael G MG
Proceedings of the National Academy of Sciences of the United States of America 20191216 52
Natural killer (NK) cells mediate vital control of cancer and viral infection. They rely on MHC class I (MHC I)-specific self-receptors to identify and lyse diseased cells without harming self-MHC I-bearing host cells. NK cells bearing inhibitory self-receptors for host MHC I also undergo education, referred to as licensing, which causes them to become more responsive to stimulation via activation receptor signaling. Previous work has shown that licensed NK cells selectively expand during virus ...[more]