Ontology highlight
ABSTRACT:
SUBMITTER: Parks KR
PROVIDER: S-EPMC6936959 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Parks K Rachael KR MacCamy Anna J AJ Trichka Josephine J Gray Matthew M Weidle Connor C Borst Andrew J AJ Khechaduri Arineh A Takushi Brittany B Agrawal Parul P Guenaga Javier J Wyatt Richard T RT Coler Rhea R Seaman Michael M LaBranche Celia C Montefiori David C DC Veesler David D Pancera Marie M McGuire Andrew A Stamatatos Leonidas L
Cell reports 20191201 10
Broadly HIV-1 neutralizing VRC01 class antibodies target the CD4-binding site of Env. They are derived from VH1-2<sup>∗</sup>02 antibody heavy chains paired with rare light chains expressing 5-amino acid-long CDRL3s. They have been isolated from infected subjects but have not yet been elicited by immunization. Env-derived immunogens capable of binding the germline forms of VRC01 B cell receptors on naive B cells have been designed and evaluated in knockin mice. However, the elicited antibodies c ...[more]