High fat diet induces microbiota-dependent silencing of enteroendocrine cells.
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ABSTRACT:
SUBMITTER: Ye L
PROVIDER: S-EPMC6937151 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
High fat diet induces microbiota-dependent silencing of enteroendocrine cells.
Ye Lihua L Mueller Olaf O Bagwell Jennifer J Bagnat Michel M Liddle Rodger A RA Rawls John F JF
eLife 20191203
Enteroendocrine cells (EECs) are specialized sensory cells in the intestinal epithelium that sense and transduce nutrient information. Consumption of dietary fat contributes to metabolic disorders, but EEC adaptations to high fat feeding were unknown. Here, we established a new experimental system to directly investigate EEC activity in vivo using a zebrafish reporter of EEC calcium signaling. Our results reveal that high fat feeding alters EEC morphology and converts them into a nutrient insens ...[more]
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