Ontology highlight
ABSTRACT:
SUBMITTER: Tan JZA
PROVIDER: S-EPMC6938271 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Tan Jing Zhi A JZA Fourriere Lou L Wang Jingqi J Perez Franck F Boncompain Gaelle G Gleeson Paul A PA
Molecular biology of the cell 20191120 1
Processing of amyloid precursor protein (APP) by the β-secretase BACE1 is the initial step of the amyloidogenic pathway to generate amyloid-β (Aβ). Although newly synthesized BACE1 and APP are transported along the secretory pathway, it is not known whether BACE1 and APP share the same post-Golgi trafficking pathways or are partitioned into different transport routes. Here we demonstrate that BACE1 exits the Golgi in HeLa cells and primary neurons by a pathway distinct from the trafficking pathw ...[more]