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Dental anomalies and orthodontic characteristics in patients with pseudohypoparathyroidism.


ABSTRACT: BACKGROUND:Pseudohypoparathyroidism (PHP) is a rare and inherited disease caused by mutations in the GNAS-gene or upstream of the GNAS complex locus. It is characterized by end-organ resistance to PTH, resulting in hypocalcemia and hyperphosphatemia. We aimed to investigate the dental anomalies according to tooth types and the orthodontic characteristics of patients with PHP. METHODS:Using a cross-sectional design, 29 patients (23 females) with PHP, living in Denmark, were included, and their clinical intraoral photos and radiographs were examined. RESULTS:Pulp calcification was found in 76% of the patients. Blunting of root apex was present in 55% and shortening of root in 48% of the examined patients. Blunting and shortening of roots were seen more often in premolars than in other tooth types (pboth?

SUBMITTER: Hejlesen J 

PROVIDER: S-EPMC6938634 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Dental anomalies and orthodontic characteristics in patients with pseudohypoparathyroidism.

Hejlesen Jane J   Underbjerg Line L   Gjørup Hans H   Sikjaer Tanja T   Rejnmark Lars L   Haubek Dorte D  

BMC oral health 20191231 1


<h4>Background</h4>Pseudohypoparathyroidism (PHP) is a rare and inherited disease caused by mutations in the GNAS-gene or upstream of the GNAS complex locus. It is characterized by end-organ resistance to PTH, resulting in hypocalcemia and hyperphosphatemia. We aimed to investigate the dental anomalies according to tooth types and the orthodontic characteristics of patients with PHP.<h4>Methods</h4>Using a cross-sectional design, 29 patients (23 females) with PHP, living in Denmark, were include  ...[more]

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