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The Human Genetics of Dental Anomalies.


ABSTRACT: The development of tooth is a highly complex procedure and mastered by specific genetic programs. Genetic alterations, environmental factors, and developmental timing can disturb the execution of these programs, and result in various dental anomalies like hypodontia/oligodontia, and supernumerary teeth, which are commonly seen in our clinical practice. Advances in molecular research enabled the identification of various genes involved in the pathogenesis of dental anomalies. In the near future, it will help provide a more accurate diagnosis and biological-based treatment for these anomalies. In this article, we present the molecular phenomenon of tooth development and the genetics of various dental anomalies.

SUBMITTER: Khan MI 

PROVIDER: S-EPMC9192175 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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The Human Genetics of Dental Anomalies.

Khan Mahamad Irfanulla MI   Ahmed Nadeem N   Neela Praveen Kumar PK   Unnisa Nayeem N  

Global medical genetics 20220225 2


The development of tooth is a highly complex procedure and mastered by specific genetic programs. Genetic alterations, environmental factors, and developmental timing can disturb the execution of these programs, and result in various dental anomalies like hypodontia/oligodontia, and supernumerary teeth, which are commonly seen in our clinical practice. Advances in molecular research enabled the identification of various genes involved in the pathogenesis of dental anomalies. In the near future,  ...[more]

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