Ontology highlight
ABSTRACT:
SUBMITTER: Drutovic D
PROVIDER: S-EPMC6939199 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Drutovic David D Duan Xing X Li Rong R Kalab Petr P Solc Petr P
The EMBO journal 20191016 1
Homologous chromosome segregation during meiosis I (MI) in mammalian oocytes is carried out by the acentrosomal MI spindles. Whereas studies in human oocytes identified Ran GTPase as a crucial regulator of the MI spindle function, experiments in mouse oocytes questioned the generality of this notion. Here, we use live-cell imaging with fluorescent probes and Förster resonance energy transfer (FRET) biosensors to monitor the changes in Ran and importin β signaling induced by perturbations of Ran ...[more]