Ontology highlight
ABSTRACT:
SUBMITTER: Lundsgaard AM
PROVIDER: S-EPMC6939602 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Lundsgaard Anne-Marie AM Fritzen Andreas M AM Nicolaisen Trine S TS Carl Christian S CS Sjøberg Kim A KA Raun Steffen H SH Klein Anders B AB Sanchez-Quant Eva E Langer Jakob J Ørskov Cathrine C Clemmensen Christoffer C Tschöp Matthias H MH Richter Erik A EA Kiens Bente B Kleinert Maximilian M
Journal of lipid research 20191112 1
Excessive circulating FAs have been proposed to promote insulin resistance (IR) of glucose metabolism by increasing the oxidation of FAs over glucose. Therefore, inhibition of FA oxidation (FAOX) has been suggested to ameliorate IR. However, prolonged inhibition of FAOX would presumably cause lipid accumulation and thereby promote lipotoxicity. To understand the glycemic consequences of acute and prolonged FAOX inhibition, we treated mice with the carnitine palmitoyltransferase 1 (CPT-1) inhibit ...[more]