Ontology highlight
ABSTRACT:
SUBMITTER: Yang D
PROVIDER: S-EPMC6940020 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Yang Dian D Qu Fangfei F Cai Hongchen H Chuang Chen-Hua CH Lim Jing Shan JS Jahchan Nadine N Grüner Barbara M BM S Kuo Christin C Kong Christina C Oudin Madeleine J MJ Winslow Monte M MM Sage Julien J
eLife 20191213
Metastasis is the main cause of death in cancer patients but remains a poorly understood process. Small cell lung cancer (SCLC) is one of the most lethal and most metastatic cancer types. SCLC cells normally express neuroendocrine and neuronal gene programs but accumulating evidence indicates that these cancer cells become relatively more neuronal and less neuroendocrine as they gain the ability to metastasize. Here we show that mouse and human SCLC cells in culture and in vivo can grow cellular ...[more]