Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC6940616 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Wang Huiling H Li Yiming Y Shi Gang G Wang Yuan Y Lin Yi Y Wang Qin Q Zhang Yujing Y Yang Qianmei Q Dai Lei L Cheng Lin L Su Xiaolan X Yang Yang Y Zhang Shuang S Li Zhi Z Li Jia J Wei Yuquan Y Yu Dechao D Deng Hongxin H
Molecular therapy oncolytics 20191214
Therapeutic antibodies targeting vascular endothelial growth factor (VEGF) have become a critical regimen for tumor therapy, but the efficacy of monotherapy is usually limited by drug resistance and multiple angiogenic mechanisms. Complement proteins are becoming potential candidates for cancer-targeted therapy based on their role in promoting cancer progression and angiogenesis. However, the antitumor abilities of simultaneous VEGF and complement blockade were unknown. We generated a humanized ...[more]