Ontology highlight
ABSTRACT:
SUBMITTER: Gimenez-Mascarell P
PROVIDER: S-EPMC6940986 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Giménez-Mascarell Paula P Oyenarte Iker I González-Recio Irene I Fernández-Rodríguez Carmen C Corral-Rodríguez María Ángeles MÁ Campos-Zarraga Igone I Simón Jorge J Kostantin Elie E Hardy Serge S Díaz Quintana Antonio A Zubillaga Lizeaga Mara M Merino Nekane N Diercks Tammo T Blanco Francisco J FJ Díaz Moreno Irene I Martínez-Chantar María Luz ML Tremblay Michel L ML Müller Dominik D Siliqi Dritan D Martínez-Cruz Luis Alfonso LA
International journal of molecular sciences 20191212 24
The four member family of "Cyclin and Cystathionine β-synthase (CBS) domain divalent metal cation transport mediators", CNNMs, are the least-studied mammalian magnesium transport mediators. CNNM4 is abundant in the brain and the intestinal tract, and its abnormal activity causes Jalili Syndrome. Recent findings show that suppression of CNNM4 in mice promotes malignant progression of intestinal polyps and is linked to infertility. The association of CNNM4 with phosphatases of the regenerating liv ...[more]