Ontology highlight
ABSTRACT:
SUBMITTER: Jadhav CK
PROVIDER: S-EPMC6941212 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
ACS omega 20191217 27
The diisopropyl ethyl ammonium acetate (DIPEAc)-promoted Biginelli protocol has been developed for the first time by a successive one-pot three-component reaction of aldehydes, ethylcyanoacetate/ethyl acetoacetate, and thiourea/urea to afford pharmacologically promising 1,2,3,4-tetrahydropyrimidines in high yields at room temperature. The key benefits of the present scheme are the capability to allow a variability of functional groups, short reaction times, easy workup, high yields, recyclabilit ...[more]