Ontology highlight
ABSTRACT:
SUBMITTER: Hu Y
PROVIDER: S-EPMC6941217 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Hu Yue Y Kumru Ozan S OS Xiong Jian J Antunez Lorena R LR Hickey John J Wang Yang Y Cavacini Lisa L Klempner Mark M Joshi Sangeeta B SB Volkin David B DB
Journal of pharmaceutical sciences 20190729 1
Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrheal disease among children in developing countries, and there are no licensed vaccines to protect against ETEC. Passive immunization by oral delivery of ETEC-specific secretory IgAs (sIgAs) could potentially provide an alternative approach for protection in targeted populations. In this study, a series of physiochemical techniques and an in vitro gastric digestion model were used to characterize and compare key structural attribut ...[more]