Ontology highlight
ABSTRACT:
SUBMITTER: Brackman DJ
PROVIDER: S-EPMC6941886 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Brackman Deanna J DJ Yee Sook Wah SW Enogieru Osatohanmwen J OJ Shaffer Christian C Ranatunga Dilrini D Denny Joshua C JC Wei Wei-Qi WQ Kamatani Yoichiro Y Kubo Michiaki M Roden Dan M DM Jorgenson Eric E Giacomini Kathleen M KM
Clinical pharmacology and therapeutics 20190523 3
Allopurinol, which lowers uric acid (UA) concentration, is increasingly being recognized for its benefits in cardiovascular and renal disease. However, response to allopurinol is variable. We gathered samples from 4,446 multiethnic subjects for a genome-wide association study of allopurinol response. Consistent with previous studies, we observed that the Q141K variant in ABCG2 (rs2231142), which encodes the efflux pump breast cancer resistance protein (BCRP), associated with worse response to al ...[more]