Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat.
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ABSTRACT:
SUBMITTER: Labi V
PROVIDER: S-EPMC6942046 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat.
Labi Verena V Peng Siying S Klironomos Filippos F Munschauer Mathias M Kastelic Nicolai N Chakraborty Tirtha T Schoeler Katia K Derudder Emmanuel E Martella Manuela M Mastrobuoni Guido G Hernandez-Miranda Luis R LR Lahmann Ines I Kocks Christine C Birchmeier Carmen C Kempa Stefan S Quintanilla-Martinez de Fend Leticia L Landthaler Markus M Rajewsky Nikolaus N Rajewsky Klaus K
Genes & development 20191107 23-24
Knockout of the ubiquitously expressed miRNA-17∼92 cluster in mice produces a lethal developmental lung defect, skeletal abnormalities, and blocked B lymphopoiesis. A shared target of miR-17∼92 miRNAs is the pro-apoptotic protein BIM, central to life-death decisions in mammalian cells. To clarify the contribution of miR-17∼92:Bim interactions to the complex miR-17∼92 knockout phenotype, we used a system of conditional mutagenesis of the nine <i>Bim</i> 3' UTR miR-17∼92 seed matches. Blocking miR ...[more]
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