SIVcpz cross-species transmission and viral evolution toward HIV-1 in a humanized mouse model.
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ABSTRACT:
SUBMITTER: Curlin J
PROVIDER: S-EPMC6942238 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
SIVcpz cross-species transmission and viral evolution toward HIV-1 in a humanized mouse model.
Curlin James J Schmitt Kimberly K Remling-Mulder Leila L Moriarty Ryan R Stenglein Mark M O'Connor Shelby S Marx Preston P Akkina Ramesh R
Journal of medical primatology 20191001 1
HIV-1 evolved from its progenitor SIV strains, but details are lacking on its adaptation to the human host. We followed the evolution of SIVcpz in humanized mice to mimic cross-species transmission. Increasing viral loads, CD4<sup>+</sup> T-cell decline, and non-synonymous mutations were seen in the entire genome reflecting viral adaptation. ...[more]
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