Management of primary refractory acute myeloid leukemia in the era of targeted therapies.
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ABSTRACT:
SUBMITTER: McMahon CM
PROVIDER: S-EPMC6945493 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Management of primary refractory acute myeloid leukemia in the era of targeted therapies.
McMahon Christine M CM Perl Alexander E AE
Leukemia & lymphoma 20180920 3
Primary refractory acute myeloid leukemia (AML), or primary induction failure, represents a continued challenge in clinical management. This review presents an overview of primary refractory disease and a discussion of risk factors for induction failure, including current evidence regarding the impact of karyotype and molecular mutation status on responsiveness to chemotherapy. We review the evidence for various treatment options for refractory AML including salvage chemotherapy regimens, alloge ...[more]
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