Ontology highlight
ABSTRACT:
SUBMITTER: Wein LA
PROVIDER: S-EPMC6946608 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Wein Lukas Anton LA Wurst Klaus K Angyal Peter P Weisheit Lara L Magauer Thomas T
Journal of the American Chemical Society 20191203 50
We present a bioinspired late-stage C-H oxidation of the <i>ent</i>-trachylobane natural product mitrephorone B to mitrephorone A. The realization of this unprecedented transformation was accomplished by either an iron-catalyzed or electrochemical oxidation and enabled access to the densely substituted oxetane in one step. Formation of mitrephorone C, which is lacking the central oxetane unit but features a keto-function at C2, was not formed under these conditions. ...[more]