Ontology highlight
ABSTRACT:
SUBMITTER: Nie H
PROVIDER: S-EPMC6946671 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Nie Hao H Ju Haixing H Fan Jiayi J Shi Xiaoliu X Cheng Yaxian Y Cang Xiaohui X Zheng Zhiguo Z Duan Xiaotao X Yi Wen W
Nature communications 20200107 1
Many cancer cells display enhanced glycolysis and suppressed mitochondrial metabolism. This phenomenon, known as the Warburg effect, is critical for tumor development. However, how cancer cells coordinate glucose metabolism through glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle is largely unknown. We demonstrate here that phosphoglycerate kinase 1 (PGK1), the first ATP-producing enzyme in glycolysis, is reversibly and dynamically modified with O-linked N-acetylglucosamine (O-Glc ...[more]