Ontology highlight
ABSTRACT:
SUBMITTER: Hitosugi T
PROVIDER: S-EPMC3500524 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Cancer cell 20121101 5
It is unclear how cancer cells coordinate glycolysis and biosynthesis to support rapidly growing tumors. We found that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1), commonly upregulated in human cancers due to loss of TP53, contributes to biosynthesis regulation in part by controlling intracellular levels of its substrate, 3-phosphoglycerate (3-PG), and product, 2-phosphoglycerate (2-PG). 3-PG binds to and inhibits 6-phosphogluconate dehydrogenase in the oxidative pentose phosphate pa ...[more]