TGF-? induces ST2 and programs ILC2 development.
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ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC6946674 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
TGF-β induces ST2 and programs ILC2 development.
Wang Li L Tang Jun J Yang Xia X Zanvit Peter P Cui Kairong K Ku Wai Lim WL Jin Wenwen W Zhang Dunfang D Goldberg Nathan N Cain Alexander A Ni Bing B Zhao Keji K Wu Yuzhang Y Chen WanJun W
Nature communications 20200107 1
The molecular pathways underlying the development of innate lymphoid cells (ILCs) are mostly unknown. Here we show that TGF-β signaling programs the development of ILC2s from their progenitors. Specifically, the deficiency of TGF-β receptor II in bone marrow progenitors results in inefficient development of ILC2s, but not ILC1s or ILC3s. Mechanistically, TGF-β signaling is required for the generation and maintenance of ILC2 progenitors (ILC2p). In addition, TGF-β upregulates the expression of th ...[more]
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