Ontology highlight
ABSTRACT:
SUBMITTER: Mylonas E
PROVIDER: S-EPMC6946829 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Nature communications 20200107 1
Cancer development is an evolutionary genomic process with parallels to Darwinian selection. It requires acquisition of multiple somatic mutations that collectively cause a malignant phenotype and continuous clonal evolution is often linked to tumor progression. Here, we show the clonal evolution structure in 15 myelofibrosis (MF) patients while receiving treatment with JAK inhibitors (mean follow-up 3.9 years). Whole-exome sequencing at multiple time points reveal acquisition of somatic mutatio ...[more]