Ontology highlight
ABSTRACT:
SUBMITTER: Oon ML
PROVIDER: S-EPMC7832336 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Oon Ming Liang ML Lim Jing Quan JQ Lee Bernett B Leong Sai Mun SM Soon Gwyneth Shook-Ting GS Wong Zi Wei ZW Lim Evelyn Huizi EH Li Zhenhua Z Yeoh Allen Eng Juh AEJ Chen Shangying S Ban Kenneth Hon Kim KHK Chung Tae-Hoon TH Tan Soo-Yong SY Chuang Shih-Sung SS Kato Seiichi S Nakamura Shigeo S Takahashi Emiko E Ho Yong-Howe YH Khoury Joseph D JD Au-Yeung Rex K H RKH Cheng Chee-Leong CL Lim Soon-Thye ST Chng Wee-Joo WJ Tripodo Claudio C Rotzschke Olaf O Ong Choon Kiat CK Ng Siok-Bian SB
Cancers 20210119 2
T-cell lymphomas arise from a single neoplastic clone and exhibit identical patterns of deletions in T-cell receptor (TCR) genes. Whole genome sequencing (WGS) data represent a treasure trove of information for the development of novel clinical applications. However, the use of WGS to identify clonal T-cell proliferations has not been systematically studied. In this study, based on WGS data, we identified monoclonal rearrangements (MRs) of T-cell receptors (TCR) genes using a novel segmentation ...[more]