Ontology highlight
ABSTRACT:
SUBMITTER: Jimenez-Vacas JM
PROVIDER: S-EPMC6947219 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Jiménez-Vacas Juan M JM Gómez-Gómez Enrique E Montero-Hidalgo Antonio J AJ Herrero-Aguayo Vicente V L-López Fernando F Sánchez-Sánchez Rafael R Guler Ipek I Blanca Ana A Méndez-Vidal María José MJ Carrasco Julia J Lopez-Miranda José J Requena-Tapia María J MJ Castaño Justo P JP Gahete Manuel D MD Luque Raúl M RM
Journal of clinical medicine 20191122 12
Recent data suggested that plasma Ghrelin O-Acyl Transferase enzyme (GOAT) levels could represent a new diagnostic biomarker for prostate cancer (PCa). In this study, we aimed to explore the diagnostic and prognostic/aggressiveness capacity of GOAT in urine, as well as to interrogate its putative pathophysiological role in PCa. We analysed urine/plasma levels of GOAT in a cohort of 993 patients. In vitro (i.e., cell-proliferation) and in vivo (tumor-growth in a xenograft-model) approaches were p ...[more]