Ontology highlight
ABSTRACT:
SUBMITTER: Chen W
PROVIDER: S-EPMC6947697 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Chen Wei W Chen Hao H Zheng Dandan D Zhang Hongbo H Deng Lianfu L Cui Wenguo W Zhang Yuhui Y Santos Hélder A HA Shen Hongxing H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20191007 1
Gene therapy provides an ideal potential treatment for intervertebral disk degeneration by delivering synthetic microRNAs (miRNAs) to regulate the gene expression levels. However, it is very challenging to deliver miRNAs directly, which leads to inactivation, low transfection efficiency, and short half-life. Here, Agomir is loaded in hydrogel to construct a gene-hydrogel microenvironment for regulating the synthesis/catabolism balance of the tissue extracellular matrix (ECM) to treat degenerativ ...[more]