Ontology highlight
ABSTRACT:
SUBMITTER: Patel SA
PROVIDER: S-EPMC6948191 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Patel Shetal A SA Minn Andy J AJ
Immunity 20180301 3
The success of immune checkpoint blockade in patients with a wide variety of malignancies has changed the treatment paradigm in oncology. However, combination therapies with immune checkpoint blockade will be needed to overcome resistance and broaden the clinical utility of immunotherapy. Here we discuss a framework for rationally designing combination therapy strategies based on enhancing major discriminatory functions of the immune system that are corrupted by cancer-namely, antigenicity, adju ...[more]