Dataset Information

Predicting Longitudinal Outcomes of Alzheimer's Disease via a Tensor-Based Joint Classification and Regression Model.

ABSTRACT: Alzheimer's disease (AD) is a serious neurodegenerative condition that affects millions of people across the world. Recently machine learning models have been used to predict the progression of AD, although they frequently do not take advantage of the longitudinal and structural components associated with multi-modal medical data. To address this, we present a new algorithm that uses the multi-block alternating direction method of multipliers to optimize a novel objective that combines multi-modal longitudinal clinical data of various modalities to simultaneously predict the cognitive scores and diagnoses of the participants in the Alzheimer's Disease Neuroimaging Initiative cohort. Our new model is designed to leverage the structure associated with clinical data that is not incorporated into standard machine learning optimization algorithms. This new approach shows state-of-the-art predictive performance and validates a collection of brain and genetic biomarkers that have been recorded previously in AD literature.

SUBMITTER: Brand L

PROVIDER: S-EPMC6948350 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Predicting Longitudinal Outcomes of Alzheimer's Disease via a Tensor-Based Joint Classification and Regression Model.

Brand Lodewijk L Nichols Kai K Wang Hua H Huang Heng H Shen Li L

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 20200101

Alzheimer's disease (AD) is a serious neurodegenerative condition that affects millions of people across the world. Recently machine learning models have been used to predict the progression of AD, although they frequently do not take advantage of the longitudinal and structural components associated with multi-modal medical data. To address this, we present a new algorithm that uses the multi-block alternating direction method of multipliers to optimize a novel objective that combines multi-mod ...[more]

PMID: 31797582

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Project description:Many machine learning and pattern classification methods have been applied to the diagnosis of Alzheimer's disease (AD) and its prodromal stage, i.e., mild cognitive impairment (MCI). Recently, rather than predicting categorical variables as in classification, several pattern regression methods have also been used to estimate continuous clinical variables from brain images. However, most existing regression methods focus on estimating multiple clinical variables separately and thus cannot utilize the intrinsic useful correlation information among different clinical variables. On the other hand, in those regression methods, only a single modality of data (usually only the structural MRI) is often used, without considering the complementary information that can be provided by different modalities. In this paper, we propose a general methodology, namely multi-modal multi-task (M3T) learning, to jointly predict multiple variables from multi-modal data. Here, the variables include not only the clinical variables used for regression but also the categorical variable used for classification, with different tasks corresponding to prediction of different variables. Specifically, our method contains two key components, i.e., (1) a multi-task feature selection which selects the common subset of relevant features for multiple variables from each modality, and (2) a multi-modal support vector machine which fuses the above-selected features from all modalities to predict multiple (regression and classification) variables. To validate our method, we perform two sets of experiments on ADNI baseline MRI, FDG-PET, and cerebrospinal fluid (CSF) data from 45 AD patients, 91 MCI patients, and 50 healthy controls (HC). In the first set of experiments, we estimate two clinical variables such as Mini Mental State Examination (MMSE) and Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), as well as one categorical variable (with value of 'AD', 'MCI' or 'HC'), from the baseline MRI, FDG-PET, and CSF data. In the second set of experiments, we predict the 2-year changes of MMSE and ADAS-Cog scores and also the conversion of MCI to AD from the baseline MRI, FDG-PET, and CSF data. The results on both sets of experiments demonstrate that our proposed M3T learning scheme can achieve better performance on both regression and classification tasks than the conventional learning methods.

Dataset Information

Predicting Longitudinal Outcomes of Alzheimer's Disease via a Tensor-Based Joint Classification and Regression Model.

Publications

Predicting Longitudinal Outcomes of Alzheimer's Disease via a Tensor-Based Joint Classification and Regression Model.

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