Ontology highlight
ABSTRACT:
SUBMITTER: Sawane K
PROVIDER: S-EPMC6950470 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Sawane Kento K Nagatake Takahiro T Hosomi Koji K Hirata So-Ichiro SI Adachi Jun J Abe Yuichi Y Isoyama Junko J Suzuki Hidehiko H Matsunaga Ayu A Fukumitsu Satoshi S Aida Kazuhiko K Tomonaga Takeshi T Arita Makoto M Kunisawa Jun J
Nutrients 20191122 12
The metabolism and generation of bioactive lipid mediators are key events in the exertion of the beneficial effects of dietary omega-3 fatty acids in the regulation of allergic inflammation. Here, we found that dietary linseed oil, which contains high amounts of alpha-linolenic acid (ALA) dampened allergic rhinitis through eosinophilic production of 15-hydroxyeicosapentaenoic acid (15-HEPE), a metabolite of eicosapentaenoic acid (EPA). Lipidomic analysis revealed that 15-HEPE was particularly ac ...[more]