Unknown

Dataset Information

0

Dietary Omega-3 Fatty Acid Dampens Allergic Rhinitis via Eosinophilic Production of the Anti-Allergic Lipid Mediator 15-Hydroxyeicosapentaenoic Acid in Mice.


ABSTRACT: The metabolism and generation of bioactive lipid mediators are key events in the exertion of the beneficial effects of dietary omega-3 fatty acids in the regulation of allergic inflammation. Here, we found that dietary linseed oil, which contains high amounts of alpha-linolenic acid (ALA) dampened allergic rhinitis through eosinophilic production of 15-hydroxyeicosapentaenoic acid (15-HEPE), a metabolite of eicosapentaenoic acid (EPA). Lipidomic analysis revealed that 15-HEPE was particularly accumulated in the nasal passage of linseed oil-fed mice after the development of allergic rhinitis with the increasing number of eosinophils. Indeed, the conversion of EPA to 15-HEPE was mediated by the 15-lipoxygenase activity of eosinophils. Intranasal injection of 15-HEPE dampened allergic symptoms by inhibiting mast cell degranulation, which was mediated by the action of peroxisome proliferator-activated receptor gamma. These findings identify 15-HEPE as a novel EPA-derived, and eosinophil-dependent anti-allergic metabolite, and provide a preventive and therapeutic strategy against allergic rhinitis.

SUBMITTER: Sawane K 

PROVIDER: S-EPMC6950470 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC5007051 | biostudies-other
| S-EPMC6902719 | biostudies-literature
| S-EPMC2833142 | biostudies-literature
| S-EPMC4363311 | biostudies-literature
| S-EPMC6513421 | biostudies-literature
| S-EPMC9382355 | biostudies-literature
| S-EPMC4414684 | biostudies-literature
| S-EPMC6681309 | biostudies-literature
| S-EPMC7322186 | biostudies-literature
| S-EPMC3253701 | biostudies-literature