Dataset Information

Bayesian Space-Time Analysis of Brain Cancer Incidence in Southern Ontario, Canada: 2010-2013.

ABSTRACT: Canada has one of the highest incidence rates of brain cancer in the world. This study investigates the space-time variation of brain cancer risk across Southern Ontario, Canada. A Bayesian spatio-temporal regression model is used to estimate the relative risk of brain cancer in the 12 spatial health units of Southern Ontario over a four-year period (2010-2013). This work also explores the association between brain cancer and two potential risk factors: traumatic head injury (THI) and excess body fat (EBF). Across all areal units from 2010-2013, results show that the relative risk of brain cancer ranged from 0.83 (95% credible interval (CI) 0.74-0.91) to 1.26 (95% CI 1.13-1.41). Over the years, the eastern and western health units had persistently higher risk levels compared to those in the central areas. Results suggest that areas with elevated THI rates and EBF levels were also potentially associated with higher brain cancer relative risk. Findings revealed that the mean temporal trend for cancer risk progression in the region smoothly decreased over time. Overall, 50% of the health units displayed area-specific trends which were higher than the region's average, thus indicating a slower decrease in cancer rates for these areas in comparison to the mean trend.

SUBMITTER: Persad RA

PROVIDER: S-EPMC6950658 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Bayesian Space-Time Analysis of Brain Cancer Incidence in Southern Ontario, Canada: 2010-2013.

Persad Ravi Ancil RA

Medical sciences (Basel, Switzerland) 20191214 12

Canada has one of the highest incidence rates of brain cancer in the world. This study investigates the space-time variation of brain cancer risk across Southern Ontario, Canada. A Bayesian spatio-temporal regression model is used to estimate the relative risk of brain cancer in the 12 spatial health units of Southern Ontario over a four-year period (2010-2013). This work also explores the association between brain cancer and two potential risk factors: traumatic head injury (THI) and excess bod ...[more]

PMID: 31847406

Similar Datasets

Project description:IntroductionAdult respiratory syncytial virus (RSV) burden is underestimated due to non-specific symptoms, limited standard-of-care and delayed testing, reduced diagnostic test sensitivity-particularly when using single diagnostic specimen-when compared to children, and variable test sensitivity based on the upper airway specimen source. We estimated RSV-attributable hospitalization incidence among adults aged ≥ 18 years in Ontario, Canada, using a retrospective time-series model-based approach.MethodsThe Institute for Clinical Evaluative Sciences data repository provided weekly numbers of hospitalizations (from 2013 to 2019) for respiratory, cardiovascular, and cardiorespiratory disorders. The number of hospitalizations attributable to RSV was estimated using a quasi-Poisson regression model that considered probable overdispersion and was based on periodic and aperiodic time trends and viral activity. As proxies for viral activity, weekly counts of RSV and influenza hospitalizations in children under 2 years and adults aged 60 years and over, respectively, were employed. Models were stratified by age and risk group.ResultsIn patients ≥ 60 years, RSV-attributable incidence rates were high for cardiorespiratory hospitalizations (range [mean] in 2013-2019: 186-246 [215] per 100,000 person-years, 3‒4% of all cardiorespiratory hospitalizations), and subgroups including respiratory hospitalizations (144-192 [167] per 100,000 person-years, 5‒7% of all respiratory hospitalizations) and cardiovascular hospitalizations (95-126 [110] per 100,000 person-years, 2‒3% of all cardiovascular hospitalizations). RSV-attributable cardiorespiratory hospitalization incidence increased with age, from 14-18 [17] hospitalizations per 100,000 person-years (18-49 years) to 317-411 [362] per 100,000 person-years (≥ 75 years).ConclusionsEstimated RSV-attributable respiratory hospitalization incidence among people ≥ 60 years in Ontario, Canada, is comparable to other incidence estimates from high-income countries, including model-based and pooled prospective estimates. Recently introduced RSV vaccines could have a substantial public health impact.

Project description:There is little consensus on the amount of worldwide food waste generation because many current estimates are indirect and link back to the same limited primary datasets, with much of the data originating from fieldwork undertaken in the 1970s and 1980s. Direct measurement of waste streams, through waste composition studies, can be used to develop accurate estimates of food waste disposal. In Ontario, Canada, municipalities that undertake household waste composition studies all use a common direct measurement methodology that includes a broad range of waste categories, including food waste. The purpose of this research was to estimate the quantity of food waste disposed, in the garbage stream, by households in southern Ontario, Canada, and determine if this common methodology could be expanded and serve as the basis of a standardized and rigorous household food waste measurement methodology. Household waste composition study data (2012-2015), including a single "food waste" category, were gathered from 9 Ontario municipalities, aggregated and analyzed to develop estimates of food waste in the garbage stream. On average, households disposed 2.40 kg/week of food waste in the garbage, which comprised 35.4% of this waste stream. This does not include any food waste otherwise disposed (e.g., sink) or recycled (e.g., composted). Urban households disposed significantly greater amounts of food waste compared to rural households in the spring (p = 0.01) and summer (p = 0.02). Households with access to a green bin program disposed significantly less food waste than those with no access to a green bin program in the spring (p = 0.03) and summer (p<0.01). The common methodology used to develop these estimates shows promise as the basis of a household food waste measurement methodology. This future methodology would include dividing food waste into avoidable and unavoidable food waste categories, as well as adding subcategories (e.g., avoidable fruits and vegetables).

Dataset Information

Bayesian Space-Time Analysis of Brain Cancer Incidence in Southern Ontario, Canada: 2010-2013.

Publications

Bayesian Space-Time Analysis of Brain Cancer Incidence in Southern Ontario, Canada: 2010-2013.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets