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Data on the optimisation of GC-MS/MS method for the simultaneous determination of compounds from food contact material.

ABSTRACT: Food contact materials (FCM) made of plastic materials contain various additives, e.g. plasticisers, UV-stabilisers, preservatives, antioxidants, etc. These compounds can migrate from the material to the food and display adverse health effects in consumers. Inertness of FCM is established by migration testing with appropriate food simulants [1]. A GC-MS/MS method for the simultaneous determination of several different groups of additives to plastics has been developed to perform a migration testing and to determine these compounds in real samples, as described in the research publication "Development of a SPME-GC-MS/MS method for the determination of some contaminants from food contact material in beverages" [2]. Here, we present the data on the optimisation of GC-MS/MS parameters: GC column and temperature programme choice, MS/MS parameters optimisation, and choice of internal standard. Subsequently, SPME parameters were also optimised as described in [2].

SUBMITTER: Znidersic L

PROVIDER: S-EPMC6950780 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Data on the optimisation of GC-MS/MS method for the simultaneous determination of compounds from food contact material.

Žnideršič Luka L Mlakar Anita A Prosen Helena H

Data in brief 20191231

Food contact materials (FCM) made of plastic materials contain various additives, e.g. plasticisers, UV-stabilisers, preservatives, antioxidants, etc. These compounds can migrate from the material to the food and display adverse health effects in consumers. Inertness of FCM is established by migration testing with appropriate food simulants [1]. A GC-MS/MS method for the simultaneous determination of several different groups of additives to plastics has been developed to perform a migration test ...[more]

PMID: 31921953

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Project description:Research of natural products from traditionally used medicinal plants to fight against the human ailments is fetching attention of researchers worldwide. Bidens pilosa Linn. var. Radiata (Asteraceae) is well known for its folkloric medicinal use against various diseases from many decades. Mizoram, North East India, has high plant diversity and the use of this plant as herbal medicine is deep rooted in the local tribes. The present study was executed to understand the pharmacological potential of B. pilosa leaves extract.The antimicrobial potential was determined using agar well diffusion and broth microdilution method against bacterial and yeast pathogens. Cytotoxicity was evaluated using MTT and apoptotic DNA fragmentation assays. Further, the antioxidant ability of the extract was analysed using DPPH and ABTS free radical scavenging assay. Mosquitocidal activity was evaluated against third in-star larvae of C. quinquefasciatus using dose response and time response larvicidal bioassay. Additionally, the major phenolic and volatile compounds were determined using UHPLC-QqQLIT-MS/MS and GC/MS respectively.We found that the extract showed highest antimicrobial activity against E. coli (MIC 80 ?g/mL and IC50 110.04 ?g/mL) and showed significant cytotoxicity against human epidermoid carcinoma (KB-3-1) cells with IC50 values of 99.56 ?g/mL among the tested cancer cell lines. The IC50 values for scavenging DPPH and ABTS was 80.45 ?g/mL and 171.6 ?g/mL respectively. The extract also showed the high phenolics (72 ?g GAE/mg extract) and flavonoids (123.3 ?g Quercetin /mg extract). Lastly, five bioactive and six volatile compounds were detected using UHPLC-QqQLIT-MS/MS and GC-MS respectively which may be responsible for the plant's bioactivities. An anticancerous compound, Paclitaxel was detected and quantified for the first time from B. pilosa leaves extract, which further showed the anticancerous potential of the tested extract.On the basis of the present investigation, we propose that the leaf extract of B. pilosa might be a good candidate for the search of efficient environment friendly natural bioactive agent and pharmaceutically important compounds.

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Data on the optimisation of GC-MS/MS method for the simultaneous determination of compounds from food contact material.

Publications

Data on the optimisation of GC-MS/MS method for the simultaneous determination of compounds from food contact material.

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