Ontology highlight
ABSTRACT:
SUBMITTER: Yousuf Y
PROVIDER: S-EPMC6950874 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Yousuf Yusef Y Datu Andrea A Barnes Ben B Amini-Nik Saeid S Jeschke Marc G MG
Stem cell research & therapy 20200108 1
<h4>Background</h4>Profound skeletal muscle wasting and weakness is common after severe burn and persists for years after injury contributing to morbidity and mortality of burn patients. Currently, no ideal treatment exists to inhibit muscle catabolism. Metformin is an anti-diabetic agent that manages hyperglycemia but has also been shown to have a beneficial effect on stem cells after injury. We hypothesize that metformin administration will increase protein synthesis in the skeletal muscle by ...[more]