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Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer

ABSTRACT: Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer

PROVIDER: PRJNA418437 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6293150.fastq.gz	Fastqsanger.gz
	SRR6293160.fastq.gz	Fastqsanger.gz
	SRR6293151.fastq.gz	Fastqsanger.gz
	SRR6293161.fastq.gz	Fastqsanger.gz
	SRR6293162.fastq.gz	Fastqsanger.gz

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Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer (RNA-Seq)

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Project description:Metastasis, the development of secondary malignant growths at a distance from a primary tumor, is the cause of death for 90% of cancer patients, but little is known about how metastatic cancer cells adapt to and colonize new tissue environments. Here, using clinical samples, patient-derived xenograft (PDX) samples, PDX cells, and primary/metastatic cell lines, we discovered that liver metastatic colorectal cancer (CRC) cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program. We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers. Further, we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription, thereby driving CRC liver metastasis. Importantly, similar transcription reprogramming can be observed in multiple cancer types. Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically.

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