Ontology highlight
ABSTRACT:
SUBMITTER: Zuo P
PROVIDER: S-EPMC6951463 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Zuo Peiying P Collins Jon J Okour Malek M Barth Aline A Shortino Denise D Yates Phillip P Roberts Grace G Watson Helen A HA Peppercorn Amanda A Hossain Mohammad M
Clinical and translational science 20191107 1
Zanamivir is a potent and highly selective inhibitor of influenza neuraminidase in which the inhibition of this enzyme prevents the virus from infecting other cells and specifically prevents release of the new virion from the host cell membrane. It is available as an oral powder for inhalation and intravenous formulations. The current population pharmacokinetic model based on data from eight studies of subjects treated with the intravenous formulation (125 healthy adults and 533 hospitalized adu ...[more]