Ontology highlight
ABSTRACT:
SUBMITTER: Lim WW
PROVIDER: S-EPMC6952089 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Lim Wei-Wen WW Ng Benjamin B Widjaja Anissa A Xie Chen C Su Liping L Ko Nicole N Lim Sze-Yun SY Kwek Xiu-Yi XY Lim Stella S Cook Stuart Alexander SA Schafer Sebastian S
PloS one 20200109 1
Interleukin 11 (IL11) is a profibrotic cytokine, secreted by myofibroblasts and damaged epithelial cells. Smooth muscle cells (SMCs) also secrete IL11 under pathological conditions and express the IL11 receptor. Here we examined the effects of SMC-specific, conditional expression of murine IL11 in a transgenic mouse (Il11SMC). Within days of transgene activation, Il11SMC mice developed loose stools and progressive bleeding and rectal prolapse, which was associated with a 65% mortality by two wee ...[more]