Dataset Information
Image-guided neural activity manipulation with a paramagnetic drug.
Ontology highlight
ABSTRACT:
SUBMITTER: Bricault S
PROVIDER: S-EPMC6952355 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Image-guided neural activity manipulation with a paramagnetic drug.
Nature communications 20200109 1
Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed with feedback from magnetic resonance imaging. We validate pharmacological properties of the compound in vitro, and show that its distribution in vivo reliably predicts perturbations to brain activit ...[more]