Ontology highlight
ABSTRACT:
SUBMITTER: Regan-Komito D
PROVIDER: S-EPMC6952438 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Regan-Komito Daniel D Swann James W JW Demetriou Philippos P Cohen E Suzanne ES Horwood Nicole J NJ Sansom Stephen N SN Griseri Thibault T
Nature communications 20200109 1
Dysregulated hematopoiesis occurs in several chronic inflammatory diseases, but it remains unclear how hematopoietic stem cells (HSCs) in the bone marrow (BM) sense peripheral inflammation and contribute to tissue damage in arthritis. Here, we show the HSC gene expression program is biased toward myelopoiesis and differentiation skewed toward granulocyte-monocyte progenitors (GMP) during joint and intestinal inflammation in experimental spondyloarthritis (SpA). GM-CSF-receptor is increased on HS ...[more]