Ontology highlight
ABSTRACT:
SUBMITTER: Deng J
PROVIDER: S-EPMC5368424 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Deng Jiusheng J Li Yanqiu Y Pennati Andrea A Yuan Shala S Wu Jian Hui JH Waller Edmund K EK Galipeau Jacques J
Molecular therapy : the journal of the American Society of Gene Therapy 20170201 2
Hematopoietic stem cells (HSCs) have the capacity to self-renew and differentiate into hematopoietic cells and have been utilized to replace diseased bone marrow for patients with cancers and blood disorders. Although remarkable progress has been made in developing new tools to manipulate HSCs for clinic use, there is still no effective method to expand HSCs in vivo for quick repopulation of hematopoietic cells following sublethal irradiation. We have recently described a novel synthetic cytokin ...[more]