Ontology highlight
ABSTRACT:
SUBMITTER: Marina N
PROVIDER: S-EPMC6952443 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Marina Nephtali N Christie Isabel N IN Korsak Alla A Doronin Maxim M Brazhe Alexey A Hosford Patrick S PS Wells Jack A JA Sheikhbahaei Shahriar S Humoud Ibrahim I Paton Julian F R JFR Lythgoe Mark F MF Semyanov Alexey A Kasparov Sergey S Gourine Alexander V AV
Nature communications 20200109 1
Astrocytes provide neurons with essential metabolic and structural support, modulate neuronal circuit activity and may also function as versatile surveyors of brain milieu, tuned to sense conditions of potential metabolic insufficiency. Here we show that astrocytes detect falling cerebral perfusion pressure and activate CNS autonomic sympathetic control circuits to increase systemic arterial blood pressure and heart rate with the purpose of maintaining brain blood flow and oxygen delivery. Studi ...[more]