Ontology highlight
ABSTRACT:
SUBMITTER: Masamoto K
PROVIDER: S-EPMC4468581 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Masamoto Kazuto K Unekawa Miyuki M Watanabe Tatsushi T Toriumi Haruki H Takuwa Hiroyuki H Kawaguchi Hiroshi H Kanno Iwao I Matsui Ko K Tanaka Kenji F KF Tomita Yutaka Y Suzuki Norihiro N
Scientific reports 20150616
Cortical neural activities lead to changes in the cerebral blood flow (CBF), which involves astrocytic control of cerebrovascular tone. However, the manner in which astrocytic activity specifically leads to vasodilation or vasoconstriction is difficult to determine. Here, cortical astrocytes genetically expressing a light-sensitive cation channel, channelrhodopsin-2 (ChR2), were transcranially activated with a blue laser while the spatiotemporal changes in CBF were noninvasively monitored with l ...[more]