Ontology highlight
ABSTRACT:
SUBMITTER: Gritsenko PG
PROVIDER: S-EPMC6952556 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Gritsenko Pavlo G PG Atlasy Nader N Dieteren Cindy E J CEJ Navis Anna C AC Venhuizen Jan-Hendrik JH Veelken Cornelia C Schubert Dirk D Acker-Palmer Amparo A Westerman Bart A BA Wurdinger Thomas T Leenders William W Wesseling Pieter P Stunnenberg Hendrik G HG Friedl Peter P
Nature cell biology 20200106 1
Diffuse brain infiltration by glioma cells causes detrimental disease progression, but its multicellular coordination is poorly understood. We show here that glioma cells infiltrate the brain collectively as multicellular networks. Contacts between moving glioma cells are adaptive epithelial-like or filamentous junctions stabilized by N-cadherin, β-catenin and p120-catenin, which undergo kinetic turnover, transmit intercellular calcium transients and mediate directional persistence. Downregulati ...[more]