Ontology highlight
ABSTRACT:
SUBMITTER: Petty AJ
PROVIDER: S-EPMC6952752 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Cells 20191127 12
The growth of hematologic malignant cells can be facilitated by other non-tumor cells within the same microenvironment, including stromal, vascular, immune and mesenchymal stem cells. Macrophages are an integral part of the human innate immune system and the tumor microenvironment. Complex interplays between the malignant hematologic cells and the infiltrating macrophages promote the formation of leukemia, lymphoma or myeloma-associated macrophages. These pro-tumorigenic macrophages in turn play ...[more]